Hexadecanamide

Hexadecanamide (Palmitamide) is a fatty acid amide that has orally active anti-allergic, antioxidant, and neuroprotective effects. Hexadecanamide exerts protective effects in Staphylococcus aureus- and SARA-induced mastitis. Hexadecanamide suppresses S. aureus-induced activation of the NF-κB pathway and improves blood-milk barrier integrity. Hexadecanamide activates PPARα. Hexadecanamide enhances sperm motility in vitro. Hexadecanamide can be studied in research for mastitis and asthenozoospermia^[1][2]. In Vitro:Hexadecanamide (Compound HEX) (5 μM, 2 h) limits the activation of mammary NF-κB via activating the PPARα-SIRT1 axis in MMECs^[1].
Hexadecanamide (10 nM, 0-72 h) exerts a significant enhancing effect on sperm motility^[2].
Hexadecanamide (0-1.5 nM, 72 h) results in a significant increase in the protein levels of both PAOX and CA2 in sperm cells^[2]. In Vivo:Hexadecanamide (Compound HEX) (1.25-5 mg/kg. p.o., 15 d) reduces mammary S. aureus loads and attenuates mammary damage in a dose-dependent manner in S. aureus infected mice^[1].
Hexadecanamide (5 mg/kg, p.o., 10 d) effectively reduces colonic inflammation in SARA mice^[1].