MLN3126
CAS No. : 628300-71-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $400 | In-stock |
| 25mg | $850 | In-stock |
| 50mg | $1350 | In-stock |
| 100mg | $1950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123763 |
| M.Wt: | 446.90 |
| Formula: | C21H19ClN2O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC50 value of 6.3 nM for calcium influx[1].
In Vitro: MLN3126 inhibits CCL25-induced calcium mobilization with an IC50 value of 6.3 nM in CCR9 expressing cells[1].
MLN3126 inhibits the binding of biotinylated CCL25 to CCR9 with an IC50 of 14.2 nM[1].
In Vivo: MLN3126 (2.5% w/w; p.o.) decreases colonic level of IFN-γ, largely produced by T cells[1].
MLN3126 (0.05, 0.25 and 1% (w/w); p.o.) has the potential activity for alleviating inflammatory bowel disease (IBD)[1].
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