SD-208 (GMP)

SD-208 (GMP) is SD-208 (HY-13227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC₅₀ of 48 nM, and > 100-fold selectivity over TGF-βRII. In Vitro:SD-208 (GMP) inhibits the cell growth and constitutive and TGF-beta-evoked migration and invasion, and enhances immunogenicity in murine SMA-560 and human LN-308 glioma cells^[1].
SD-208 (GMP) blocks TGF-beta-induced phosphorylation of the receptor-associated Smads, Smad2 and Smad3, and stimulates epithelial-to-mesenchymal transdifferentiation, migration, and invasiveness into Matrigel in vitro^[2].
SD-208 (GMP) also abolishes the promoting effect of TGF-β on neointimal smooth muscle-like cell (SMLC) proliferation and migration in vitro^[3]. In Vivo:SD-208 (GMP) (1 mg/mL, p.o.) significantly prolongs the median survival of SMA-560 glioma-bearing mice^[1].
In syngeneic 129S1 mice, SD-208 (GMP) (60 mg/kg/d, p.o.) inhibits primary R3T tumor growth, and reduces the number and the size of lung metastases^[2].
In the murine aortic allograft model, SD-208 (GMP) effectively reduces the formation of intimal hyperplasia of transplant arteriosclerosis (TA)^[3].