SKF 38393 (hydrochloride)
CAS No. : 62717-42-4
(Synonyms: (±)-SKF-38393 hydrochloride; SKF-38393A)
| Size | Price | Stock |
|---|---|---|
| 50mg | $86 | In-stock |
| 100mg | $125 | In-stock |
| 200mg | $211 | In-stock |
| 500mg | $462 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-12520A |
| M.Wt: | 291.77 |
| Formula: | C16H18ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 34 mg/mL;H2O : 10 mg/mL (ultrasonic) |
SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].
IC50 & Target: IC50: 110 nM (D1DR)
In Vitro: SKF-38393 hydrochloride induces a similar change in cytomorphology and increases the levels of media cAMP[2].
SKF-38393 hydrochloride (10 μmol/L; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2].
In Vivo: SKF-38393 hydrochloride (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3].
SKF-38393 hydrochloride attenuates MPTP-induced depletion of dopamine[3].
SKF-38393 hydrochloride enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
SKF-38393 hydrochloride enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].
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