NSC 15830

S-(1,2-Dichlorovinyl)-L-cysteine is the Trichloroethylene metabolite, inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro. Target: TNF-α in vitro: S-(1,2-Dichlorovinyl)-L-cysteine inhibits pathogen stimulated cytokine release from tissue punch cultures. S-(1,2-Dichlorovinyl)-L-cysteine (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. S-(1,2-Dichlorovinyl)-L-cysteine effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue punch cultures of extraplacental membranes. S-(1,2-Dichlorovinyl)-L-cysteine effects on GBS-stimulated release of pro-inflammatory cytokines from extraplacental membranes in transwell cultures.