GSK-3b Inhibitor XI
CAS No. : 626604-39-5
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|---|---|---|
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| Cat. No. : | HY-112388 |
| M.Wt: | 349.34 |
| Formula: | C18H15N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming) |
GSK-3b Inhibitor XI (Compound 33) is a potent and selective GSK3β inhibitor, with a Ki value of 25 nM. GSK-3b Inhibitor XI increases glycogen synthase (GS) activity. GSK-3b Inhibitor XI can be used for research on type 2 diabetes and Alzheimer’s disease[1].
In Vitro:GSK-3b Inhibitor XI increases glycogen synthase (GS) activity in HEK293 cells (EC50 = 32 nM) [1].
GSK-3b Inhibitor XI (5 μM) has high metabolic stability in human liver microsomes, with T1/2 of >100 min[1].
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