Bopindolol
CAS No. : 62658-63-3
(Synonyms: (±)-Bopindolol)
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| Cat. No. : | HY-B1562 |
| M.Wt: | 380.48 |
| Formula: | C23H28N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research. IC50 & Target:Adrenergic receptor, Renin, 5-HT receptors[1][4] In Vivo:Bopindolol (intravenous injection; 8, 16 and 32 μg/kg) causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs[1]. Bopindolol (0.3, 1 and 3 mg/kg; IP; single dosage) produces dose dependent decreases in diastolic blood pressure and in heart rate[2].
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