LY-503430


CAS No. : 625820-83-9

625820-83-9
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Cat. No. : HY-122164
M.Wt: 392.49
Formula: C20H25FN2O3S
Purity: >98 %
Solubility:
Introduction of 625820-83-9 :

LY-503430 is an orally active AMPA receptor positive allosteric modulator (PAM). LY-503430 can be used for the study of Parkinson's disease[1]. In Vitro:The submicromolar concentrations of LY-503430 (0.03-10 μM) selectively enhances glutamate-induced calcium influx into human embryonic kidney 293 cells transfected with human GLUA1, GLUA2, GLUA3, or GLUA4 AMPA receptors. LY-503430 also potentiates AMPA-mediated responses in native cortical, hippocampal, and substantia nigra neurons[1]. In Vivo:LY503430 (0.5 mg/kg; s.c; once a day; for 11 days) has functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease[1].

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