3-Hydroxyisovaleric acid
CAS No. : 625-08-1
| Size | Price | Stock |
|---|---|---|
| 5g | $5 | In-stock |
| 10g | $6 | In-stock |
| 25g | $12 | In-stock |
| 100g | $32 | In-stock |
| 500g | $138 | In-stock |
| 1000g | $265 | In-stock |
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| Cat. No. : | HY-113409 |
| M.Wt: | 118.13 |
| Formula: | C5H10O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
3-Hydroxyisovaleric acid is a normal endogenous metabolite excreted in the urine. The urinary excretion of 3-hydroxyisovaleric acid is early and sensitive indicator of biotin deficiency[1][2]. In Vitro: The reduced activity of methylcrotonyl-CoA carboxylase (MCC) leads to an elevated excretion of 3-methylcrotonic acid, the product of its hydration (3-hydroxyisovaleric acid: 3-HIA), and 3-methylcrotonylglycine, formed by conjugation with glycine[2]. In Vivo: In male mice (ICR/Jcl) at 8 weeks of age fed the biotin-deficient diet for 6 weeks, the concentration of urinary 3-Hydroxyisovaleric acid is 114.2 mM creatinine, which is higher than the concentration of 35.2 mM creatinine in mice fed the biotin-deficient diet for 4 weeks[2].
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