Dihydro-5-azacytidine
CAS No. : 62488-57-7
(Synonyms: DHAC; NSC 264880)
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| Cat. No. : | HY-106689 |
| M.Wt: | 246.22 |
| Formula: | C8H14N4O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Dihydro-5-azacytidine (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine has an antitumor activity[1][2].
In Vitro: Methylation studies show that an LD10 dose of [3H]DHAC results in a 25.06% hypomethylation of DNA in L1210/0 cells and a 46.32% hypomethylation in a deoxycytidine kinase mutant cell line L1210/dCK(-), compared with their respective controls[2].
Dihydro-5-azacytidine (DHAC) competes with cytidine triphosphate for incorporation into RNA, leading to ribosomal degradation and defective protein synthesis[1].
In Vivo: In tumor-bearing mice (injected with L1210/0 cells), after an LD10 dose of Dihydro-5-azacytidine (DHAC; 1500 mg/kg), the plasma peak concentration achieved is 317 μM and is eliminated biexponentially, with a t1/2 α of 1.03 h and a t1/2 β of 5 h[2].
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