Ursonic acid
CAS No. : 6246-46-4
(Synonyms: 3-Ketoursolic acid)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $60 | In-stock |
| 25mg | $80 | In-stock |
| 50mg | $110 | In-stock |
| 100mg | $165 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N1486 |
| M.Wt: | 454.68 |
| Formula: | C30H46O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 80°C);H2O : < 0.1 mg/mL |
Ursolic acid is a naturally occurring triterpenoid that has orally active. Ursolic acid induces the apoptosis of human cancer cells through multiple signaling pathways. Ursolic acid has anti-inflammatory and anticarcinogenic activity[1][2].
In Vitro:Ursolic acid (12.5-50 μM, 48 h) induce apoptosis in T24 human bladder cancer cells in a dose-dependent manner by inhibiting AKT/NF-κB signaling[1].
Ursolic acid (50 μM, 2-4 h) increases the expression of p53 and caspase-3 and decreases bcl-2 gene expression in B16F-10 melanoma cells[2].
Ursolic acid (10-50 μM, 48 h) inhibits the production of TNF-α, IL-1β, IL-6 and GM-CSF in B16F-10 melanoma cells[2].
Ursolic acid (50 μM, 2 h) inhibits the NF-κB subunits (p65, p50 and c-Rel) and nuclear translocation of c-fos, ATF-2 and CREB-1 in B16F-10 melanoma cells[2].
In Vivo:Ursolic acid (5-20 mg/kg, p.o., twice a day, 30 days) protects against ethanol-mediated experimental liver injury in adult male albino rats[3].
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