PD 407824
CAS No. : 622864-54-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $125 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $440 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18961 |
| M.Wt: | 328.32 |
| Formula: | C20H12N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2].
IC50 & Target: IC50: 47 nM (Chk1), 97 nM (WEE1)[1]
In Vitro: PD 407824 is sufficient to block CHK1, leading to a significant down-regulation of p21, causing activation of CDK8/9, which in turn causes depletion of SMAD2/3[1].
PD 407824 is selective for Chk1 and WEE1 over PKC and Cdk4 with IC50s of 3.4 µM and 3.75 µM, respectively[3].
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