PIP-199
CAS No. : 622795-76-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $250 | In-stock |
| 10mg | $420 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-124325 |
| M.Wt: | 456.54 |
| Formula: | C27H28N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 41.67 mg/mL (ultrasonic;warming;heat to 80°C) |
PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics[1].
IC50 & Target: IC50: 36 μM (RMI core complex/MM2 interaction)[1]
In Vitro: MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM)[1].
Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies[1].
Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents[1].
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