OXSI-2
CAS No. : 622387-85-3
| Size | Price | Stock |
|---|---|---|
| 500μg | $66 | Get quote |
| 1mg | $100 | In-stock |
| 5 mg | Get quote | |
| 10 mg | Get quote | |
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| Cat. No. : | HY-112386 |
| M.Wt: | 353.40 |
| Formula: | C18H15N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming) |
OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM[1][2].
In Vitro: OXSI-2 (2 μM) completely inhibits Convulxin-induced platelet aggregation and shape change. OXSI-2 (2 μM) also completely blocks GPVI-mediated dense granule release. OXSI-2 (100 nM) does not affect the platelet functional responses induced by Convulxin, and modest shape change is still evident at 1 μM[1].
Adaptor protein LAT is a known substrate of Syk Kinase. OXSI-2 completely inhibits LAT Y191 phosphorylation. OXSI-2 inhibits Syk mediated events in platelets[1].
OXSI-2 (2 μM) inhibits inflammasome assembly, caspase-1 activation, IL-1β processing and release, mitochondrial ROS generation, and pyroptotic cell death[2].
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