THS-044
CAS No. : 62054-67-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $260 | In-stock |
| 10mg | $420 | In-stock |
| 50mg | $980 | In-stock |
| 100mg | $1350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19621 |
| M.Wt: | 291.23 |
| Formula: | C11H12F3N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
THS-044 is a modulator of the formation of the HIF2α/ARNT heterodimer. THS-044 binding stabilizes the HIF2α PAS-B folded state (KD = 2 μM), for regulating HIF2 activity in endogenous and pathological settings, and does not bind to HIF1α or ARNT PAS-B. THS-044 increases the KD of the heterodimer formed by HIF2α PAS-B and ARNT PAS-B from 120 μM to 400 μM. THS-044 can be used for the study of diseases related to hypoxia[1][2].
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