AFN-1252
CAS No. : 620175-39-5
(Synonyms: API-1252; Debio 1452)
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 50mg | $600 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-16911 |
| M.Wt: | 375.42 |
| Formula: | C22H21N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 5.8 mg/mL (ultrasonic) |
AFN-1252 is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC90 values of ⩽0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith[1][2]. In Vitro:AFN-1252 is extremely potent against clinical isolates of S. aureus (MIC90, 0.015 μg/ml) and coagulase-negative staphylococci (MIC90, 0.12 μg/ml)[2] In Vivo:AFN-1252 (0.03-3 mg/kg; oral gavage; single dose) is efficacious in a mouse model of septicemia, with 100% survival obtained with a single oral dose of 1 mg/kg[2].
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