Dirithromycin
CAS No. : 62013-04-1
(Synonyms: LY237216)
| Size | Price | Stock |
|---|---|---|
| 100mg | $35 | In-stock |
| 500mg | $65 | In-stock |
| 1g | $100 | In-stock |
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| Cat. No. : | HY-B0643 |
| M.Wt: | 835.07 |
| Formula: | C42H78N2O14 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic);Ethanol : ≥ 50 mg/mL |
Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis[1][2].
In Vitro: Dirithromycin possesses an in vitro spectrum of antimicrobial activity which is similar to that of Erythromycin[2].
Dirithromycin exhibits excellent in vitro activity against several strains of Legionella, with MICs of ~1.0 and <0.25 μg/mL at pH=7.1 and 7.4, respectively[2].
Dirithromycin demonstrates potent activity against several strains of Helicobacter pytori, with MICs of <0.5 μg/mL[2].
In Vivo: Dirithromycin (s.c. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 1.0, 0.6, and <0.6 mg/kg[2].
Dirithromycin (p.o. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 27, 34, and 23 mg/kg[2].
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