CCG-63802
CAS No. : 620112-78-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $390 | In-stock |
| 100mg | $627 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-70074 |
| M.Wt: | 450.51 |
| Formula: | C26H18N4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 1.67 mg/mL (ultrasonic;warming) |
CCG-63802 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gαo interaction, with an IC50 value of 1.9 μM[1]. In Vitro: CCG-63802 (5 μM) inhibits regulators of G-protein signaling (RGS) proteins in the presence of BK (bradykinin) and 8-Br-cGMP (membrane-permeable analogue of cGMP), HEK-293 cells start to depolarize again[2]. In Vivo: CCG-63802 (0.05 mg/kg; intratracheal administration; once per week; 90 days) reduces RGS4 protein expression, leading to partially abrogate the attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodeling[3].
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