Paroxetine

Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches^[1][2][3][4]. In Vitro:Paroxetine (10-30 μM, 72 h) reduces the viability of MCF-7 cells in a time- and dose-dependent manner^[1].
Paroxetine (10-30 μM, 1-12 h) induces mitochondrial-mediated apoptosis in MCF-7, increasing ROS generation^[1]. In Vivo:Paroxetine (10 mg/kg, intraperitoneally, once a day for 14 days) reduces neurogenic pain in rats both before and after sciatic nerve injury^[2].
Paroxetine (0.3-10 mg/kg, orally, single dose) has anti-anxiety and antidepressant effects in rats, increasing social interaction time^[3].