7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
CAS No. : 61563-24-4
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| Cat. No. : | HY-113969 |
| M.Wt: | 202.08 |
| Formula: | C9H9Cl2N |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1]. In Vivo: 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) (i.p., 40 mg/kg, once daily, 3 days) has an important role in the regulation of blood pressure and changes in adrenal catecholamine levels in rats[2].
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