M62812 (free base)
CAS No. : 613262-61-6
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| Cat. No. : | HY-103639 |
| M.Wt: | 257.31 |
| Formula: | C13H11N3OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis[1].
In Vitro:M62812 (0-10 μg/ml) suppresses LPS-induced upregulation of inflammatory cytokines, adhesion molecules and procoagulant activity in human vascular endothelial cells and peripheral mononuclear cells[1].
In Vivo:M62812 (i.v.; 10-20 mg/kg; single) protects mice from lethality and reduced inflammatory and coagulatory parameters in a murine d-galactosamine-sensitized endotoxin shock model[1].
M62812 (20 mg/kg/day) prevents mice from lethality in a murine cecal ligation and puncture model[1].
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