Hh-Ag1.5
CAS No. : 612542-14-0
(Synonyms: SAg1.5)
| Size | Price | Stock |
|---|---|---|
| 1mg | $156 | In-stock |
| 5mg | $390 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $995 | In-stock |
| 50mg | $1400 | In-stock |
| 100mg | $1960 | In-stock |
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| Cat. No. : | HY-124899 |
| M.Wt: | 526.04 |
| Formula: | C28H26ClF2N3OS |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM[1]. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure[2].
IC50 & Target: EC50: 1 nM (Hedgehog)[1]
In Vitro: HhAg1.5 (5 μM; for 3 weeks) facilitates dramatic expansion of quiescent CD133+ CD45- liver stem cells (Hh3A cells) enriched from non-injured liver in vitro[2].
Hh-Ag1.5 competely binds to the Smo-containing membranes with the Ki value of 0.52 nM[3].
The Smo agonist SAG-1.5 displays nanomolar-range potency stimulation of Gli-responsive reporter activity, with an EC50 of 7 nM[4].
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