Tiopinac
CAS No. : 61220-69-7
(Synonyms: RS 40974)
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|---|---|---|
| 1mg | $255 | In-stock |
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| Cat. No. : | HY-U00063 |
| M.Wt: | 284.33 |
| Formula: | C16H12O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tiopinac (RS 40974), a dibenzthiepin, is an orally active and highly potent anti-inflammatory and anti-pyretic agent[1]. In Vivo: Tiopinac (0.03-110 mg/kg) has 40 times the antiphlogistic potency of phenylbutazone. The dose required to reduce paw swelling by 30% is approximately 0.5 mg/kg. Tiopinac does not elicit overt side effects at the 20 mg/kg/day dose. Tiopinac causes a dose-related reversal of the decreases body weight caused by the adjuvant disease, the weight of those rats receiving 0.135 and 0.4 mg/kg/day being significantly greater than that of the positive controls. Tiopinac (0.3-30 mg/kg) is highly potent in inhibiting the pain evoked in the yeastinflamed hind paw of the rat[1].
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