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|---|---|---|
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| Cat. No. : | HY-122529 |
| M.Wt: | 478.45 |
| Formula: | C18H30N4O11 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus[1][2][3].
In Vivo:Almurtide (80 mg/kg; once daily for 4 consecutive days; via intraperitoneal, intravenous, or subcutaneous) stimulates macrophages nonspecifically and has anti-infective activity against Listeria monocytogenes. At the same time, it lacks oral activity and is synergistic with Gentamicin (HY-A0276A)[2].
Almurtide (100 μg/mouse; s.c.; once for 2-3 months) prevents erythroleukemia in SJL/J mice caused by low-dose Friend leukemia virus and delays the occurrence of spontaneous breast tumors in RIII/Imr mice[3].
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