Asukamycin
CAS No. : 61116-33-4
| Size | Price | Stock |
|---|---|---|
| 500μg | $782 | Get quote |
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| Cat. No. : | HY-118893 |
| M.Wt: | 546.61 |
| Formula: | C31H34N2O7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines[1][2].
In Vitro:Asukamycin (1-50 μM; 24 h) in a concentration-dependent manner reduces viability of five different human cell lines with IC50 of 1-5 μM[1].
Asukamycin (50 μM; 24 and 72 h; THP-1 cells) causes a significant increase in intracellular caspase 8 and caspase 3 activity[1].
Asukamycin (0-100 mcg/mL; bacteria, 18 h; fungus, 72 h) has antimicrobial activity. Asukamycin inhibits the growth of Gram-positive bacteria within a concentration range of 0.78-12.5 mcg/mL and inhibits the growth of Trichophyton mentagrophytes at a concentration of 25 mcg/ mL[2].
In Vivo:Asukamycin (0-450 mg/kg; i.p.; mice) has low toxicity in vivo. Asukamycin has acute toxicity with an LD50 value of 48.5 mg/kg by intraperitoneal injection[2].
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