Cyclic-di-GMP
CAS No. : 61093-23-0
(Synonyms: c-di-GMP; cyclic diguanylate; 5GP-5GP)
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| Cat. No. : | HY-107780 |
| M.Wt: | 690.41 |
| Formula: | C20H24N10O14P2 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 25 mg/mL |
Cyclic-di-GMP is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP can be used in cancer research[1][2][3][4].
IC50 & Target:STING[1][2][3][4].
In Vitro:Cyclic-di-GMP (0.5-50 μM; 5 days) inhibits proliferation of human colon cancer cells[1].
Cyclic-di-GMP (0.5-50 μM; 5 days) specifically elevates CD4 expression in Jurkat cells[2].
Cyclic-di-GMP (0.5-50 μM; 5 days) induces cell cycle arrest at the S-phase in Jurkat cells[2].
In Vivo:Cyclic-di-GMP (100 μg/per; i.v.; two sequential vaccinations 9 days apart) enhances TriVax-induced immune responses to melanoma in mice and further increased the anti-tumor effects of TriVax[3].
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