Carvedilol (phosphate hemihydrate)
CAS No. : 610309-89-2
(Synonyms: BM 14190 (phosphate hemihydrate))
| Size | Price | Stock |
|---|---|---|
| 25mg | $30 | In-stock |
| 50mg | $42 | In-stock |
| 100mg | $59 | In-stock |
| 250mg | $105 | In-stock |
| 500mg | $150 | In-stock |
| 1g | $210 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-B0006A |
| M.Wt: | 513.48 |
| Formula: | C24H26N2O4.H3PO4.1/2H2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker[1]. Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome[3].
IC50 & Target:β/α-1 adrenergic receptor[1]
IC50: 5 μM (lipid peroxidation)[2]
Autophagy[3]
In Vitro: Superoxide generation by activated human neutrophils in vitro is inhibited by Carvedilol with an IC50 of 28 μM. Carvedilol is shown to scavenge oxygen free radicals in a cell-free system with an IC50 of 25 μM[2].
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