Mefenamic acid


CAS No. : 61-68-7

61-68-7
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Cat. No. : HY-B0574
M.Wt: 241.29
Formula: C15H15NO2
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL;H2O : < 0.1 mg/mL (ultrasonic)
Introduction of 61-68-7 :

Mefenamic acid is a BBB-permeable and non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. IC50 & Target:IC50: 40 nM (hCOX-1), 3 μM (hCOX-2)[1] In Vitro:Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1]. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid[2].

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