Prostratin
CAS No. : 60857-08-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $500 | In-stock |
| 10mg | $950 | In-stock |
| 25mg | $2000 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-107421 |
| M.Wt: | 390.47 |
| Formula: | C22H30O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Prostratin, a natural terpenoid compound, is a PKC activator, with a Ki of 12.5 nM and shows inhibitory effect on HIV-1.
IC50 & Target:Ki: 12.5 nM (PKC)[1]
HIV-1[1]
In Vitro:Prostratin inhibits [3H]PDBu binding to the CEM cells with a Ki of 210 nM[1].
Prostratin (125-1000 nM) dose-dependently inhibits the growth of acute myeloid leukemia (AML) cell lines (HL-60, NB4, and U937 cells). Prostratin (125-100 nM) induces G1 arrest of AML cells and affects the cell-cycle-related molecules (pRb phosphorylation, CDKs, and p21) in HL-60 cells. Prostratin also causes differentiation in AML cell lines via activation of PKC. Furthermore, PKC-dependent activation of the MEK/ERK/MAP signaling pathway requires differentiation induced by Prostratin[2].
Prostratin induces HIV-1 transcription activation requiring active form of PKD3. Prostratin also activates PKD3 via PKCε of novel PKC subfamily[3].
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