Clocapramine (dihydrochloride hydrate)
CAS No. : 60789-62-0
(Synonyms: 3-Chlorocarpipramine (dihydrochloride hydrate))
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| Cat. No. : | HY-B2073A |
| M.Wt: | 572.01 |
| Formula: | C28H41Cl3N4O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors. IC50 & Target: D2 receptor, 5-HT2A receptor[1]. In Vivo: Clocapramine shows the lowest potency for D2-occupancy in vivo[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50 of 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2)[2].
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