A 77-01
CAS No. : 607737-87-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $103 | In-stock |
| 10mg | $155 | In-stock |
| 25mg | $270 | In-stock |
| 50mg | $378 | In-stock |
| 100mg | $530 | In-stock |
| 250mg | $877 | In-stock |
| 500mg | $1185 | In-stock |
| 1g | $1600 | Get quote |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-78349 |
| M.Wt: | 286.33 |
| Formula: | C18H14N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM[1].
IC50 & Target: IC50: 25 nM (ALK5)[1]
In Vitro: A-77-01 (0.01-10 µM; 25 hours; Mv1Lu cells) treatment effectively inhibits TGF-β-induced transcriptional activation in concentration-dependent fashion[1].
A-77-01 (1 µM; 24-72 hours; Mv1Lu cells) treatment efficiently prevents the growth-inhibitory effects of TGF-β[1].
A-77-01 (1 µM; 30 minutes; HaCaT cells) treatment inhibits TGF-β-induced phosphorylation of Smad2[1].
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