BCR-ABL-IN-13
CAS No. : 607702-99-8
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| Cat. No. : | HY-112404 |
| M.Wt: | 363.40 |
| Formula: | C16H11F2N3OS2 |
| Purity: | >98 % |
| Solubility: |
BCR-ABL-IN-13 is a dual c-Src and Abl inhibitor, with a Ki value of 0.55 μM against c-Src, 0.10 μM against wild-type Abl, and 0.40 μM against the AblT315I mutant. BCR-ABL-IN-13 exerts competitive/mixed-type inhibitory effects on wild-type Abl, and non-competitive inhibitory effects on the drug-resistant AblT315I mutant. BCR-ABL-IN-13 can be used for the research of chronic myeloid leukemia[1]. In Vitro:BCR-ABL-IN-13 (compound 5) shows potent cytotoxicity against murine myeloid clones expressing either imatinib-sensitive or imatinib-resistant Bcr-Abl[1].
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