DCEBIO

DCEBIO is a small/medium conductance calcium-activated potassium (SK_Ca/IK_Ca) channel opener and primary neuron signal blocker. It hyperpolarizes the membrane potential of C2C12 myoblasts by activating IK_Ca channels, thereby promoting myogenic differentiation. The specific biological activity of DCEBIO is manifested in increased myotube formation, enhanced myosin heavy chain II protein levels and myogenin mRNA levels. DCEBIO can be applied in the field of muscle research, especially in muscle-related degenerative diseases such as sarcopenia^[1][2][3]. IC50 & Target:Cl^- secretion^[1] In Vitro:DCEBIO (10 μM; 4 days) significantly increases myotube formation, myosin heavy chain II protein expression levels, and myogenin mRNA expression levels in C2C12 myoblasts cultured in differentiation medium. DCEBIO also hyperpolarizes the membrane potential of C2C12 myoblasts in a concentration-dependent manner^[1].
DCEBIO (5 μM) disruptes the vagal firing coding generated by serotonin when added to the intestinal serosa before serotonin perfusion in isolated mouse jejunal segments in vitro, as evidenced by changes in the mean interspike interval, burst duration, and gap duration^[2].