P-1075
CAS No. : 60559-98-0
| Size | Price | Stock |
|---|---|---|
| 2mg | $100 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
| 50mg | $728 | In-stock |
| 100mg | $950 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-108573 |
| M.Wt: | 231.30 |
| Formula: | C12H17N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].
IC50 & Target:EC50: 45 nM (SUR2-KIR6)[1].
In Vitro:P1075 (3 nM) induces monophasic inhibition curves by competition-binding experiments, in the presence of MgATP[1].
P1075 (100 µM; 10 min) leads to rabbit cardiomyocytes to produce ROS in a KATP-dependent fashion[2].
P1075 (150 nM) reduces infarct size in isolated rabbit hearts compared to control animals (10.6% of the area at risk vs. 31.5%, P < 0.05)[2].
In Vivo:P1075 (intravenous injection; 1μg/kg; once) treatment shows the reduction of infarct size in ischemia model[3].
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