Pifithrin-β


CAS No. : 60477-34-1

(Synonyms: PFT β; Cyclic Pifithrin-α)

60477-34-1
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Cat. No. : HY-16702
M.Wt: 268.38
Formula: C16H16N2S
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 60477-34-1 :

Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM. IC50 & Target: IC50: 23 μM (p53)[1] In Vitro: Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β (PFT β), the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].

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