Alpha-Naphthoflavone
CAS No. : 604-59-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 20mg | $140 | In-stock |
| 50mg | $210 | In-stock |
| 100mg | $320 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-125833 |
| M.Wt: | 272.30 |
| Formula: | C19H12O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis[1][2][3][4].
IC50 & Target:IC50: 0.5 μM (Aromatase)[1]
Ki: 0.2 μM (Aromatase)[1]
In Vitro:Alpha-Naphthoflavone (0.01-100 μM, 5 min) induces vascular relaxation by inducing extracellular calcium inflow and NO formation[2].
Alpha-Naphthoflavone (0.01-100 μM, 48 h) can inhibit HeLa cell proliferation, block the G1/S phase, and increase p53 level and apoptosis[3].
Alpha-Naphthoflavone (5, 10, 20, 40 μM, 24 h) can protect HepG2 hepatocytes treated with oleic acid (OA)[4].
In Vivo:Alpha-Naphthoflavone (80, 160 mg/kg/day, gavage for 4 weeks) has protective effects on NAFLD mice induced by high-fat diet (HFD)[4].
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