Bufuralol (hydrochloride)
CAS No. : 60398-91-6
(Synonyms: Ro 3-4787 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $430 | In-stock |
| 10mg | $690 | In-stock |
| 25mg | $1500 | In-stock |
| 50mg | $2400 | In-stock |
| 100mg | $3850 | In-stock |
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| Cat. No. : | HY-105124A |
| M.Wt: | 297.82 |
| Formula: | C16H24ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming);Ethanol : 15 mg/mL (ultrasonic;warming) |
Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate[1][2]. In Vitro:Bufuralol (Ro 3-4787) hydrochloride is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates[3]. In Vivo:Bufuralol (Ro 3-4787) hydrochloride metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers[4].
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