Sulprostone
CAS No. : 60325-46-4
(Synonyms: SHB 286; CP-34089; ZK-57671)
| Size | Price | Stock |
|---|---|---|
| 10.74 mM * 200 μL in Methyl acetate | $350 | In-stock |
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| Cat. No. : | HY-19360 |
| M.Wt: | 465.56 |
| Formula: | C23H31NO7S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery[1][2][3].
In Vitro: Sulprostone (SHB 286) has Ki values of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells[1].
Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs[2].
In Vivo: Sulprostone (SHB 286; 0.5 mg/kg; IV) has a T1/2 of 0.451 hours, a CL of 56 mL/min•kg, a Vss of 0.583 L/kg and an AUC of 149 ng•h/mL[3].
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