E-mail  
Home
 
AboutUs
 
Service
 
Products
 
Order Information
 
Contact us
Insert title here
Featured Products
HY-100001  |  SKF-96365 (hydrochloride)
HY-100002  |  ML162
HY-100003  |  ML210
HY-100004  |  Fumarate hydratase-IN-1
HY-100005  |  Fumarate hydratase-IN-2
HY-100006  |  MRT68921
HY-100007  |  TAK-438 (free base)
HY-100008  |  Peretinoin
HY-100009  |  Ufenamate
HY-10001  |  Calcipotriol
HY-100010  |  Sulfathiourea
HY-100011  |  SR-3029
HY-100012  |  CBR-5884
HY-100013A  |  (1R,2R)-2-PCCA
HY-100013B  |  (1S,2S)-2-PCCA
HY-100014  |  KDM5A-IN-1
HY-100015  |  Mivebresib
HY-100016  |  AZD0156
HY-100017  |  BAY-876
HY-100018  |  BAY1125976
more    
Products
HY-10012

CAS:602306-29-6

602306-29-6  Technical Data: Price and Availability of  Cas No:602306-29-6

Cas : 602306-29-6 M.Wt: 371.4566
Cas : 602306-29-6 Formula: C18H21N5O2S
Cas : 602306-29-6 Purity: >98 %
Cas : 602306-29-6 Storage: at 20℃ 2 years
Cas : 602306-29-6 Solubility: 10 mM in DMSO
Cas : 602306-29-6 Name: AZD-5438
USD
10mg/$60 In-stock
50mg/$180 In-stock
100mg/$320 In-stock
1g Get quote
5g Get quote
>10g Get quote
We match the lowest price on market.
We offer a substantial discount on larger orders,please
inquire via sales@chemexpress.cn
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
Online Inquiry
 
602306-29-6  Data Sheet:
 
Introduction of 602306-29-6 :
AZD-5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It also inhibits GSK3β, but is less potent to CDK5/6. IC50 & Target: IC50: 16 nM (CDK1), 6 nM (CDK2), 20 nM (CDK9) [1] In Vitro: AZD5438 potently inhibits the kinase activity of cyclin E-cdk2, cyclin A-cdk2, cyclin B1-cdk1, p25-cdk5, cyclin D3-cdk6, and cyclin T-cdk9 (IC50, 6, 45, 16, 21, and 20 nM, respectively). AZD5438 potently inhibits the kinase activity of cyclin E-cdk2, cyclin A-cdk2, cyclin B1-cdk1, p25-cdk5, cyclin D3-cdk6, and cyclin T-cdk9 (IC50, 6, 45, 16, 21, and 20 nM, respectively). In common with many other cdk inhibitors, AZD5438 also inhibits the kinase activity of p25-cdk5 and glycogen synthase kinase 3β in vitro (IC50, 14 and 17 nM, respectively)[1]. AZD5438 significantly augments cellular radiosensitivity in NSCLC cells. Combined treatment with AZD5438 and irradiation also enhances tumor growth delay, with an enhancement factor ranging from 1.2-1.7[2]. In Vivo: AZD5438 (50 mg/kg twice daily or 75 mg/kg, p.o.) inhibits human tumor xenograft growth. In vivo, AZD5438 reduces the proportion of actively cycling cells. Further pharmacodynamic analysis of AZD5438-treated SW620 xenografts shows that efficacious doses of AZD5438 (>40% tumor growth inhibition) maintains suppression of biomarkers, such as phospho-pRbSer249/Thr252, for up to 16 hours following a single oral dose[1].
 
References on 602306-29-6 :
 

Keywords: buy AZD-5438 | AZD-5438 Supplier | purchase AZD-5438 | AZD-5438 cost | AZD-5438 manufacturer | order AZD-5438 | AZD-5438 distributor | AZD-5438 structure
buy 602306-29-6 | 602306-29-6 Supplier | purchase 602306-29-6 | 602306-29-6 cost | 602306-29-6 manufacturer | order 602306-29-6 | 602306-29-6 distributor | 602306-29-6 structure
Insert title here
 
Products are for research use only. Not for human use. We do not sell to patients.           Copyright © 2009 Haoyuan Chemexpress All Rights Reserved
ADDRESS: 6/F, No. 2 Building, No. 720,Cailun Road, Shanghai, P.R.China  
TEL:
86-21-58998590   FAX: 86-21-53700326, 86-21-58998590   E-mail: sales@chemexpress.cn