Prostaglandin J2
CAS No. : 60203-57-8
(Synonyms: PGJ2)
| Size | Price | Stock |
|---|---|---|
| 14.95 mM * 100 μL in Methyl acetate | $202 | Get quote |
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| Cat. No. : | HY-113366 |
| M.Wt: | 334.45 |
| Formula: | C20H30O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD)[1][2][3][4].
In Vivo: Prostaglandin J2 (PGJ2; 33.4 μg/injection; unilateral injection to the SNpc; once per week for 2 or 4 weeks) induces progressive PD-like pathology and exhibites microglia and astrocyte activation and motor deficits in the rats[4].
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