Sodium 4-aminosalicylate (dihydrate)


CAS No. : 6018-19-5

(Synonyms: 4-Aminosalicylic acid (sodium salt dihydrate))

6018-19-5
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Cat. No. : HY-I0447A
M.Wt: 211.15
Formula: C7H10NNaO5
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic)
Introduction of 6018-19-5 :

Sodium 4-aminosalicylate dihydrate (4-Aminosalicylic acid sodium salt dihydrate) is an inhibitor for dihydrofolate reductase (DHFR) and an antituberculous agent. Sodium 4-aminosalicylate dihydrate exhibits anti-inflammatory activity and can be used in research of inflammatory bowel disease (IBD). Sodium 4-aminosalicylate dihydrate is orally active[1][1][3]. In Vitro:Sodium 4-aminosalicylate dihydrate is incorporated into the folate pathway via dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate the hydroxydihydrofolate antimetabolite, which in turn inhibits DHFR enzyme activity[1].
Sodium 4-aminosalicylate dihydrate inhibits M. tuberculosis H37Rv growth with MIC value of 0.4 μM[1].

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