α-L-Rhamnose

α-L-Rhamnose is a neutral sugar present in plants, animals, viruses and bacteria. α-L-Rhamnose is a ligand for α-L-rhamnose-recognizing lectin sites, trigger intracellular signaling pathways. α-L-Rhamnose induces rhaE and rhaA expression as a specific carbon source in Aspergillus nidulans, while glucose inhibits its cellular uptake. α-L-Rhamnose induces rapid and transient increases in intracellular free Ca²⁺ concentration in normal human dermal fibroblasts^[1][2]. In Vitro:α-L-Rhamnose (10 μg/mL; ~15 minutes) triggers early, transient increases in intracellular free Ca²⁺ concentration in a subset of normal human dermal fibroblasts (NHDFs)^[1].
α-L-Rhamnose (1% w/v; 1-24 h) induces rapid transcriptional upregulation of rhaE and rhaA in both Aspergillus nidulans wild-type and creA^d30 derepressed strains, with greater transcript accumulation observed in the creA^d30 strain^[2].
α-L-Rhamnose (1% w/v; up to 48 h) is consumed by Aspergillus nidulans wild-type and creA^d30 derepressed strains over 48 h, inducing extracellular α-L-rhamnosidase activity, while concurrent glucose presence blocks it uptake and enzyme activity in both strains^[2].
α-L-Rhamnose (1% w/v; up to 30 h) is consumed by Aspergillus nidulans creA^d30 derepressed strain over 30 h, inducing α-L-rhamnosidase activity, while concurrent ethanol presence does not block uptake but still prevents enzyme activity^[2].