[Met5]-Enkephalin, amide


CAS No. : 60117-17-1

(Synonyms: 5-Methionine-enkephalin amide)

60117-17-1
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Cat. No. : HY-P1467
M.Wt: 572.68
Formula: C27H36N6O6S
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 60117-17-1 :

[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors. IC50 & Target: δ and ζ opioid receptor[1] In Vitro: [Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].

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