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|---|---|---|
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| Cat. No. : | HY-P1467 |
| M.Wt: | 572.68 |
| Formula: | C27H36N6O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors. IC50 & Target: δ and ζ opioid receptor[1] In Vitro: [Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].
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