Oxalic acid (diammonium monohydrate)

Oxalic acid (Ethanedioic acid) diammonium monohydrate is a dicarboxylic acid found in a wide variety of plants.
Oxalic acid diammonium monohydrate shows antioxidant acyivity and suppresses lipid peroxidation.
Oxalic acid diammonium monohydrate is a pathogenicity factor for sclerotinia sclerotiorum, and suppresses the oxidative burst of the host plant. Oxalic acid diammonium monohydrate exerts acaricidal activity. Oxalic acid can be used for the researches of sclerotinia disease varroatosis and inflammatory diseases^[1][2][3]. In Vitro:Oxalic acid (4-32 mM; 10 min) diammonium monohydrate suppresses Fe³⁺-ADP/NADPH-induced lipid peroxidation in rat liver microsomes in a concentration-dependent manner, with 32 mM reducing levels to 5.9% of control values^[1].
Oxalic acid (16 mM; 90 min) diammonium monohydrate almost completely suppresses lipid peroxidation in rat brain homogenate, reducing TBARS levels to 10% of control values^[1].
Oxalic acid (0.5-8.0 mM; 5 min) diammonium monohydrate reduces Cu²⁺/H₂O₂-induced oxidation of ascorbic acid in a cell-free in vitro system in a concentration-dependent manner, with 8.0 mM maintaining the highest ascorbate levels after 5 min of incubation^[1].
Oxalic acid (4-10 mM) diammonium monohydrate inhibits OGA-induced oxidative burst in suspension-cultured Glycine max cells with an IC₅₀ of 4 mM and achieves maximal inhibition at 6 mM^[2].
Oxalic acid (4-10 mM) diammonium monohydrate inhibits oxidative bursts induced by multiple distinct elicitors in suspension-cultured tobacco and soybean cells with IC₅₀ values of 4 to 5 mM and achieves maximal inhibition at 6 to 7 mM^[2].
Oxalic acid (10 mM) diammonium monohydrate increases OGA-induced cytosolic Ca²⁺ transients in aequorin-transformed suspension-cultured tobacco cells rather than inhibiting them^[2].