Tiazofurin
CAS No. : 60084-10-8
(Synonyms: NSC 286193; Riboxamide)
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| 50mg | $146 | In-stock |
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| Cat. No. : | HY-114570 |
| M.Wt: | 260.27 |
| Formula: | C9H12N2O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer[1][2][3][4].
In Vitro:Tiazofurin (10 μM, 0-3 days) affects growth kinetics and promotes erythroid differentiation in K562 human leukemia cells, while significantly increasing the percentage of benzidine-positive cells and elevating glycophorin A (GpA) expression[1].
Tiazofurin (10 μM, 2 days) enhances IL-6 autosecretion in K562 cells[1].
In Vivo:Tiazofurin (200-700 mg/kg, i.p., qd, days 1-9) exerts significant anti-tumor efficacy in sensitive murine transplanted tumor models (P388/L1210 leukemia in CDF1 mice, Lewis lung carcinoma in B6C3F1 mice)[2].
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