Glabrone
CAS No. : 60008-02-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $180 | In-stock |
| 5mg | $450 | In-stock |
| 10mg | $690 | In-stock |
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| Cat. No. : | HY-N4194 |
| M.Wt: | 336.34 |
| Formula: | C20H16O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity[1][2][3].
In Vitro:Glabrone (0.1-100 μM) inhibits the Oseltamivir (HY-13317)-susceptible viral NA of influenza virus PR/8/34 at concentrations lower than 10 μM[1].
Glabrone (0-50 μM, 48 h) significantly inhibits the cytopathic effect (CPE) of J/8178/09 (H1N1), and showed moderate inhibitory activity against HK/68 (H3N2) in Madin Darby canine kidney (MDCK) cells[1].
Glabrone exhibits Vmax and Km values of 362.6 nmol/min/mg protein and 17.2 μM for human liver microsomes (HLMs), and 382.3 nmol/min/mg protein and 16.6 μM for recombinant human UGT1A9, respectively[3].
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