Mepazine
CAS No. : 60-89-9
(Synonyms: Pecazine)
| Size | Price | Stock |
|---|---|---|
| 25mg | $115 | In-stock |
| 50mg | $175 | In-stock |
| 100mg | $255 | In-stock |
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| Cat. No. : | HY-121282 |
| M.Wt: | 310.46 |
| Formula: | C19H22N2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC50s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis[1]. IC50 & Target: MALT1[1] In Vitro: Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells[1]. In Vivo: Mepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rgnull (NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10[1].
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