Phlorizin (Standard)
CAS No. : 60-81-1
(Synonyms: Floridzin (Standard))
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| Cat. No. : | HY-N0143R |
| M.Wt: | 436.41 |
| Formula: | C21H24O10 |
| Purity: | >98 % |
| Solubility: |
Phlorizin (Floridzin) (Standard) is the analytical standard of Phlorizin. This product is intended for research and analytical applications. Phlorizin is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC50 of 0.04 μM and a Ki of 39 nM against hSGLT2, and an IC50 of 0.17 μM and a Ki of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities[1][2][3][4].
IC50 & Target:Ki: 300 nM (hSGLT1), 39 nM (hSGLT2)[1]
Na+/K+-ATPase[2]
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