Antipyrine
CAS No. : 60-80-0
(Synonyms: Phenazone; Phenazon)
| Size | Price | Stock |
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| 500g | $65 | In-stock |
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| Cat. No. : | HY-B0171 |
| M.Wt: | 188.23 |
| Formula: | C11H12N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL |
Antipyrine (Phenazone) is an orally active antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine also delays gastric emptying (GE) in rats[1][2][3][4].
In Vitro:Antipyrine (0.1-100 mM, 15 min) metabolites are formed by at least six hepatic cytochrome P450 enzymes (CYPlA2, CYP2B6, CYP2C8, CYP2C9, CYP2C18, and CYP3A4) in human liver microsomes[3].
In Vivo:Antipyrine (45.17 mg/kg, i.v., 10 minutes before the evaluation of gastric retention) delays gastric emptying (GE) of liquid in rats with the participation of the vagus nerve, which is blocked by the activation of GABAB receptors in the central nervous system[4].
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