Eniluracil
CAS No. : 59989-18-3
(Synonyms: 5-Ethynyluracil; GW776C85)
| Size | Price | Stock |
|---|---|---|
| 100mg | $60 | In-stock |
| 250mg | $96 | In-stock |
| 1g | $252 | In-stock |
| 5g | $893 | Get quote |
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| 50 g | Get quote | |
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| Cat. No. : | HY-10533 |
| M.Wt: | 136.11 |
| Formula: | C6H4N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
Eniluracil (5-Ethynyluracil) is an orally active dihydropyrimidine dehydrogenase (DPD) inhibitor. Eniluracil irreversibly inhibits DPD, increases the oral bioavailability of 5-fluorouracil to 100%, and facilitates the uniform absorption and toxicity of 5-fluorouracil. Eniluracil can be used in cancer research of combination with fluoropyrimidines (including 5-fluorouracil)[1][2]. Eniluracil is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IC50 & Target:Dihydropyrimidine dehydrogenase[1][2]. In Vivo:Eniluracil (5-Ethynyluracil) (1 mg/kg; i.p.; single daily for 3 days) exhibits neither toxicity nor intrinsic antitumor activity, and greatly improves FUra (5-fluorouracil) therapy in rats[1].
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